Sight Sciences announces publication of 36-month analysis of OMNI Surgical System in managing primary open-angle glaucoma

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Sight Sciences has announced the publication of a 36-month analysis evaluating the long-term effectiveness of the OMNI Surgical System in managing primary open-angle glaucoma (POAG).

The study, led by Nathan M Radcliffe, MD, of Mount Sinai School of Medicine in New York City, was published in the American Journal of Ophthalmology and based on data from the American Academy of Ophthalmology IRIS Registry.

Radcliffe stated in a press release from Sight Sciences¹, “This analysis represents one of the most comprehensive, real-world evaluations of standalone canaloplasty and trabeculotomy in these patient populations to date. Our findings underscore the ability of OMNI to achieve significant and sustained reductions in IOP and medication use over three years, reinforcing its position as a highly effective interventional treatment for patients with primary open-angle glaucoma.”

In the study, 230 eyes of 196 patients with POAG were evaluated through up to 36 months. According to the company, results show clinically and statistically significant reductions in intraocular pressure (IOP) through up to 36 months postoperatively, with mean reductions ranging from 5.6 to 7.1 mmHg. Additionally, the study reported a statistically significant decrease in medication use through 18 months.¹

The mean baseline IOP in patients evaluated was 22.1 (with a standard deviation of 6.4) mmHg, Over the 36-month follow-up, mean IOP ranged from 15.1 to 16.7 mmHg. In addition, the company noted that greater reductions in IOP were seen in high-baseline IOP patients. Patients with a baseline of 18 mmHg or higher had reductions of up to 8.9 mmHg.¹

Both patients with high baseline and low baseline IOP had reductions in medication use through 36 months. Mean number of glaucoma medications at baseline was 2.1 and ranged from 1.1 to 1.6 between 6 and 36 months.¹

The OMNI Surgical System is indicated for canaloplasty followed by trabeculotomy to reduce intraocular pressure in adult patients with POAG.

References:

1. Sight Sciences Announces Real-World 36-Month Study Confirming Long-Term Effectiveness of Standalone OMNI Surgical System in Managing Primary Open-Angle Glaucoma. Press Release. Published January 7, 2025. Accessed January 8, 2025. https://www.sightsciences.com/us/sight-sciences-announces-real-world-36-month-study-confirming-long-term-effectiveness-of-standalone-omni-surgical-system-in-managing-primary-open-angle-glaucoma/