Editor, Ophthalmology Times
Biocon achieves settlement agreement with Regeneron to launch aflibercept biosimilar, Yesafili, in the US
This agreement allows a launch in the US in the second half of 2026 or earlier in certain circumstances.
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Eyestem releases positive results from phase 1 trial in patients with geographic atrophy
Eyecyte-RPE is a suspension of human induced pluripotent stem cell–derived retinal pigment epithelial cells.
Nextech and Ocuco partner to deliver seamless end-to-end eyecare platform
The partnership will integrate Ocuco’s optical software solution, Acuitas 3, with Nextech’s Ophthalmic Platform.
Vantage Biosciences doses first patient in phase 2 study of VX-01, oral therapy for non-proliferative diabetic retinopathy
VX01-DR-201, is a phase 2, multi-center, double-masked, randomized, placebo-controlled study in patients with moderate to severe NPDR without center-involved diabetic macular edema (CI-DME).
Pykus Therapeutics completes enrollment in trial evaluating PYK-2101
PYK-2101 is a focal hydrogel retinal sealant for use in patients undergoing surgery for a detached retina.
Opthea to lay off approximately 65% of company
The announcement follows the decision to discontinue the COAST and ShORe trials in wet age-related macular degeneration after the COAST trial failed to meet its primary end point.
FDA accepts biologics license application from Outlook Therapeutics for ONS-5010 for the treatment of wet AMD
A Prescription Drug User Fee Act (PDUFA) goal date of August 27, 2025, was set by the organization.
Alumis and Acelyrin file a definitive proxy statement for proposed merger
Each company will hold a respective special meeting of stockholders to vote on the approval of the merger.
Santen receives marketing authorization application approval from NMPA of China for tafluprost/timolol maleate (Tapcom) in patients with open-angle glaucoma
Tapcom is a preservative-free, fixed-combination eye drop of tafluprost 0.0015% and timolol 0.5% for lowering intraocular pressure.
Part 6: Biggest innovations in ophthalmology in 50 years
In celebration of Ophthalmology Times 50th anniversary, we asked leading experts in the field what they see as the biggest innovation in ophthalmology in the last 5 decades.
Part 5: Biggest innovations in ophthalmology in 50 years
Part 4: Biggest innovations in ophthalmology in 50 years
Doctors warn TikTok & Instagram reels may be damaging eyes long-term
Recent estimates show that there are over 2 billion users on Instagram, of which over 726.8 million interact with reels on the platform.
Avisi Technologies releases 6-month interim results from VITA trial
The trial is designed to assess the safety and effectiveness of Avisi Technologies' investigational VisiPlate device in patients with open-angle glaucoma.
FDA issues Complete Response Letter to Aldeyra Therapeutics for resubmitted New Drug Application of reproxalap
The company stated that the FDA noted at least one additional adequate and well controlled study to demonstrate a positive effect on the treatment of ocular symptoms of dry eye should be conducted.
Part 3: Biggest innovations in ophthalmology in 50 years
OKYO Pharma releases positive long-term stability data for urcosimod in neuropathic corneal pain
Urcosimod (formerly known as OK-101) has been shown to be stable for over 2 and a half years in single-use ampoules used for administration of the drug to patients.
Opthea discontinues COAST and ShORe trials in wet AMD
The decision to discontinue the trials comes shortly after the announcement that COAST missed its primary endpoint.
Part 2: Biggest innovations in ophthalmology in 50 years
Part 1: Biggest innovations in ophthalmology in 50 years
Labtician Ophthalmics announces commercial launch of Lab TRIACTIV
Lab TRIACTIV is powered by “advanced cationic liposomal technology” for dry eye relief.
Pantheon Vision and Eyedeal Medical enter collaborative agreement to develop bioengineered corneal implant
Pantheon Vision’s bioengineered corneal implant aims to tackle issues with the success rate of human donated tissue.
Alcon acquires majority interest in Aurion Biotech
Aurion is developing AURN001, a clinical-stage allogeneic cell therapy asset, for corneal edema secondary to corneal endothelial disease.
Nanoscope Therapeutics publishes clinical data on vision restoration in retinitis pigmentosa
Administered via intravitreal injection, Synthopsin-MCO-010 possesses a promoter to specifically target ON-bipolar cells.
Character Biosciences secures $93 million series B financing round
The funding will help fund phase 1 and phase 2 proof-of-concept studies for lead candidates CTX203 and CTX114.
Alcon agrees to purchase LENSAR
The acquisition also includes the ALLY Robotic Cataract Laser Treatment System, LENSAR’s proprietary Streamline software technology and LENSAR legacy laser system.
Opthea phase 3 clinical trial, COAST, in patients with wet age-related macular degeneration fails to meet primary endpoint
The trial evaluated sozinibercept (2 mg) every 4 or 8 weeks in combination with aflibercept (2 mg), as per label, every 8 weeks after a loading phase for the treatment of wet AMD.
Unity Biotechnology releases topline results from phase 2b ASPIRE trial of UBX1325 in patients with diabetic macular edema
UBX1325 is a novel BCL-xL inhibitor designed to eliminate senescent cells in diabetic retinal blood vessels, while leaving healthy ones intact.
Glaucoma Research Foundation announces 2025 recipients of Shaffer Research Grants
The 9 recipients receive $55,000 in seed money for collaborative projects that target one or more of the foundation’s strategic research goals.
Kalaris and AlloVir Inc. complete merger
The combined companies will operate under the name Kalaris Therapeutics, Inc. and expects to report initial data from part 1 of its ongoing phase 1 clinical trial of TH103 in treatment-naïve nAMD patients in the second half of 2025.