Publication

Article

Digital Edition

Ophthalmology Times: January 2023
Volume48
Issue 1

Glaucoma surgical device lowers IOP level

Author(s):

Minimally invasive, novel system achieves significant pressure level reductions.

The surgical device is an FDA-cleared instrument for delivering small volumes of ophthalmic viscoelastic during ocular surgery

The surgical device is an FDA-cleared instrument for delivering small volumes of ophthalmic viscoelastic during ocular surgery

Reviewed by Gabriel Lazcano-Gomez, MD

A minimally invasive glaucoma surgical device called the STREAMLINE surgical System from New World Medical, Inc successfully lowered intraocular pressure (IOP) level and demonstrated a good short-term safety profile, according to Gabriel Lazcano-Gomez, MD, who reported 3-month interim results with the device. Lazcano-Gomez is in private practice in Puebla, Mexico.

The surgical device is an FDA-cleared instrument for delivering small volumes of ophthalmic viscoelastic during ocular surgery. The single-use, disposable instrument consists of a polymer handset tipped with a surgical stainless steel cannula with a long, thin neck that accesses the trabecular meshwork through a clear corneal incision. An actuator button on the handset, when depressed, retracts a polymer outer sleeve from a stainless steel inner cutting cannula tip and delivers viscoelastic, facilitating transluminal dilation over several hours.

First-in-human study

A prospective first-in-human interim analysis evaluated the surgical system in a study that included 52 eyes at 3 surgical sites. In this study, the device was used following phacoemulsification in patients with mild to moderate open-angle glaucoma (OAG) and postwashout IOP level of 22 to 34 mmHg. After the cataract procedure, the surgical procedure was performed in 1 eye. Using a surgical gonioscope, 5 applications of viscoelastic were injected into the Schlemm canal, Lazcano-Gomez explained.

The investigators collected data on IOP levels, medications, and surgical complications. The patients were followed postoperatively on day 1, week 1, and months 1 and 3.

Lazcano-Gomez reported that the average IOP level decreased significantly at each follow-up visit. Decrease in IOP level ranged from 5.5 to 8 mmHg. At month 3, the IOP level decreased by an average of 34.2% (P<.05) compared with baseline. The average number of glaucoma medications used also decreased significantly (P<.05), from 2.1 medications during the screening visit to 0.8 medications at month 3. A transient IOP level spike between week 1 and month 1 experienced by 1 patient resolved with topical treatment.

Lazcano-Gomez said he believes the device has a promising future. “The Streamline Surgical System successfully lowered the IOP [level] when used to perform transluminal dilation of Schlemm canal [when] combined with phacoemulsification in eyes with mild to moderate OAG,” Lazcano-Gomez explained. “The procedure was associated with decreased dependence on IOP [level]–lowering medications and had a favorable safety profile similar to other minimally invasive glaucoma surgical techniques.”

Gabriel Lazcano-Gomez, MD
E: drlazcano.glaucoma@gmail.com
Lazcano-Gomez is a consultant to New World Medical, Inc.

Related Videos
(Image credit: Ophthalmology Times) AGS 2025: A look at Gemini and the MIGS revolution with Mona Kaleem, MD
(Image credit: Ophthalmology Times) AGS 2025: Development and evaluation of an AI model to set target IOP with Jithin Yohannan, MD, MPH
(Image credit: Ophthalmology Times) AGS 2025: Achieving success as an academic ophthalmologist with Thomas V. Johnson III, MD, PhD
(Image credit: Ophthalmology Times) AGS 2025: Constance Okeke, MD, highlights 1-year Streamline canaloplasty outcomes
(Image credit: Ophthalmology Times) AGS 2025: Telemedicine and genetics for resource-efficient care with Louis R. Pasquale, MD
(Image credit: Ophthalmology Times) AGS 2025: Two-year data of bio-interventional cyclodialysis with scleral allograft with Leon W. Herndon Jr, MD
© 2025 MJH Life Sciences

All rights reserved.