β1 and β3 integrins use two distinct pathways to regulate CLAN formation
October 1st 2007Take-home message: New discoveries about the signaling pathways regulating cross-linked actin network (CLAN) formation could in the future lead to new therapeutic approaches for steroid-induced glaucoma. CLANs are found in glaucomatous trabecular meshwork cells as well as steroid-treated cell and eye organ cultures, thus the discovery of two distinct signaling pathways is a preliminary step toward targeting of specific proteins associated with steroid-inducedglaucoma.
Replicated loci linked to primary open-angle glaucoma
October 1st 2007Researchers have completed a genome scan of 128 families with primary open-angle glaucoma (POAG) and replicated loci on chromosomes 15 and 2. Nearly one-third of the families are of African-American or Ghanaian descent, a group disproportionately affected by POAG.
Role of TGF-β2 in open-angle glaucoma becoming clear
October 1st 2007Transforming growth factor beta (TGF-β2) increases outflow resistance in human anterior segments. Recent analysis has identified several candidate molecules and pathways by which elevated levels of TGF-b2 may trigger changes in outflow resistance.
Several factors key for multifocal IOL success
October 1st 2007Achieving high patient satisfaction rates with newer multifocal IOLs requires attention to a variety of details preoperatively, intraoperatively, and postoperatively. R. Bruce Wallace, MD, and Samuel Masket, MD, review important considerations for maximizing outcomes.
Multimodal strategies maximize success with multifocal IOL implantation
October 1st 2007Rigorous preoperative evaluation and counseling, meticulous surgery, and thorough postoperative counseling are all critical elements for optimizing outcomes with presbyopia-correcting lenticular surgery. One surgeon shares his four-step approach to excellent functional results and high patient satisfaction.
Little difference in postoperative flare between two phaco technologies on day 1
October 1st 2007No substantial differences have been seen in the amount of postoperative flare present on day 1 following cataract surgery using either micro-coaxial phacoemulsification with a torsional handpiece or micropulse phacoemulsification.
Patients with uveitis and cataract present challenges
October 1st 2007Patients with uveitis who require cataract surgery present challenges to the surgeon at every stage of care. The uveitis must be controlled carefully preoperatively, small pupils are especially problematic during surgery, and inflammation must be controlled postoperatively.
Bilateral surgery shows promise for Marcus-Gunn jaw winking synkinesis
October 1st 2007Bilateral frontalis suspension combined with levator transection and transposition appears to be a better technique for treatment of Marcus-Gunn jaw winking synkinesis, suggest results of a large case series reviewed for this rare condition.
Ablation with bipolar wet-field diathermy safe, effective for low-flow vascular lesions of orbit
October 1st 2007Ablation with bipolar wet-field diathermy is effective and safe as a management approach for low-flow vascular lesions, which typically are difficult to treat. Also, it is a less invasive strategy than standard surgery. One surgeon shares his experience.
Supranuclear gaze disturbances can be confusing
October 1st 2007Supranuclear gaze palsy should be suspected in patients with bilateral and symmetric vertical or horizontal gaze difficulty. Use of specific maneuvers to bypass the supranuclear input to the ocular motor nuclei can help to establish a supranuclear localization to the problem and direct neuroimaging to the supranuclear pathways in the brain and brainstem.
Solid-state laser can achieve excellent results for high, mixed astigmatism
October 1st 2007An analysis of results achieved from performing LASIK with a 213-nm solid-state refractive laser (Pulzar Z1, CustomVis) in 10 eyes with high and mixed astigmatism (mean astigmatism, –5.2 D) demonstrate its safety, predictability, and efficacy. Uncorrected visual acuity after a minimum of 8 weeks' follow-up was 20/30 or better in 100% of eyes.
Customized IOL implantation may be worthwhile
October 1st 2007Customized IOL implantation has become a topic of great interest over the past year. The combined implantation of two different multifocal lenses, an apodized diffractive lens (AcrySof ReSTOR, Alcon Laboratories) and a refractive lens (ReZoom, Advanced Medical Optics), has provided patients with good results in near, intermediate, and distance vision because the two IOLs complement one another. In a survey of patients in whom the diffractive lens had been implanted bilaterally and patients in whom one of each IOL had been implanted, the combination approach received higher marks compared with bilateral diffractive lens implantation.
Artificial cornea holds promise for high-risk eyes
October 1st 2007Several situations are associated with a high risk of failure after donor corneal transplantation. Encouraging results have been seen with a particular keratoprosthesis (Boston KPro, Massachusetts Eye and Ear Infirmary) as an alternative in carefully selected eyes.
Statin use appears not to protect against CNV or GA in AMD patients
October 1st 2007Statin use does not appear to have a significant protective effect against choroidal neovascularization or geographic atrophy in patients with age-related macular degeneration, according to a recent analysis of data collected during the Complications of Age-related Macular Degeneration Prevention Trial.
Fundus lesions of advanced AMD decrease visual acuity within 5 years
October 1st 2007Vision loss is associated with increasing scores on the simplified severity scale for age-related macular degeneration (AMD) in the Age-Related Eye Disease Study. A correlation also has been found between vision loss and the four fundus lesions associated with advanced AMD. These findings suggest that the fundus lesions could be used as surrogates in prevention studies for development of advanced AMD.
Diabetic retinopathy on the rise in Pakistan
October 1st 2007Reliable measurement of the distance between a phakic refractive IOL and the crystalline lens is important in detecting direct contact, a risk factor for induced cataract. In a recent study using optical coherence tomography, investigators found that the phakic refractive IOL and anterior lens surface moved forward in all cases during accommodation; mechanical contact was infrequent but was found in all instances in which opacification developed.
Accommodating IOL enhances near vision, according to phase III trial
September 15th 2007Interim results from a phase III study evaluating an accommodating IOL (Tetraflex [KH-3500], Lenstec) for pseudophakic correction after cataract surgery demonstrate that it provides good near and distance uncorrected visual acuity outcomes along with a favorable safety profile.
Can't live with them, can't live without them
September 15th 2007There are three types of employees: climbers, quitters, and some who camp at mediocrity. Practice administrators who get to know their employees and what makes them tick will contribute to the success of the practice. It may be a matter of uncovering his or her true talents and finding the right place for that person within the practice.