SpyGlass Pharma completes enrollment in Phase I/II study of its long-term drug delivery platform for glaucoma and ocular hypertension

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SpyGlass Pharma announced completion of enrollment in its Phase I/II, randomized, multi-center, controlled clinical trial (NCT06120842) evaluating SpyGlass’ drug delivery platform in patients with glaucoma or ocular hypertension.

According to the company, its platform is designed to deliver multiple years of bimatoprost to lower intraocular pressure (IOP) and is implanted during routine cataract surgery.¹

“Chronic eye conditions, such as glaucoma, can lead to vision loss and significantly impact quality of life. That’s why SpyGlass is singularly focused on making a difference for those in need,” said Patrick Mooney, SpyGlass Pharma’s CEO. “Completing enrollment in this study is an important milestone in our efforts to bring the SpyGlass technology to millions of patients around the world. We look forward to continued engagement with the FDA as we advance our platform toward two large Phase III trials.”

Malik Kahook, MD, co-founder of SpyGlass Pharma, noted the platform has demonstrated potential for improving care in glaucoma patients undergoing routine cataract surgery.

“As the SpyGlass platform is implanted using standard surgical techniques, it could significantly expand the integration of glaucoma treatment into routine cataract procedures,” Kahook said. “This could enhance adoption across a broad spectrum of surgeons and practices, setting our platform apart from currently available glaucoma interventions.”

Kahook also lauded the efforts of investigators and patients involved in the study.

“We are deeply grateful to the investigators and patients whose participation has been essential to advancing this clinical trial,” Kahook said. “Their trust and commitment have helped bring us closer to delivering a treatment that could significantly enhance care for glaucoma patients worldwide.”

The SpyGlass Drug Delivery Platform with bimatoprost is designed to deliver 3 years of bimatoprost to targeted tissues. SpyGlass will continue to release data from both the first-in-human study, which was recently published with 18-month data, and this Phase I/II study as it becomes available.¹

Reference

1. Spyglass Pharma, Inc. SpyGlass Pharma Completes Enrollment in Phase I/II Study of its Promising Long-Term Drug Delivery Platform for Glaucoma and Ocular Hypertension. GlobeNewswire News Room. Published November 19, 2024. Accessed November 19, 2024. https://www.globenewswire.com/news-release/2024/11/19/2983547/0/en/SpyGlass-Pharma-Completes-Enrollment-in-Phase-I-II-Study-of-its-Promising-Long-Term-Drug-Delivery-Platform-for-Glaucoma-and-Ocular-Hypertension.html