News

Iowa City, IA-The constricted pupil is both easy and hard to diagnose. As with the dilated pupil, there are easy-to-diagnose conditions in the patient with a small pupil-such as physiologic anisocoria, Horner's syndrome, and iris abnormalities-and these occur commonly. Pharmacologic miosis, Adie's pupil, and aberrant regeneration of the third nerve, however, are a bit harder to pinpoint, according to Andrew G. Lee, MD, who outlined his practical approach to diagnosing the constricted pupil.

New York-Structure does predict function, George A. (Jack) Cioffi, MD, told participants in the Glaucoma 2004 meeting here, and therefore measurement of the optic nerve head is important in assessing the presence and progression of the disease.

Patients need to know when an additional fee may be warranted or if the procedure will be free.

Vancouver, British Columbia-In the absence of other risk factors, eyes with a post-LASIK initial residual stromal thickness (RST)

Fort Lauderdale, FL-Accumulating evidence is providing support for the hypothesis that elevated iron levels in the retina may be a factor in the pathogenesis of age-related macular degeneration (AMD), said Joshua Dunaief, MD, PhD

Fort Lauderdale, FL-A new analysis of baseline data collected in participants of the Age-Related Eye Disease Study (AREDS) reveals a higher intake of lutein/zeaxanthin was associated with a decreased likelihood of having advanced age-related macular degen- eration (AMD). The results were reported by John Paul SanGiovanni, ScD, at the annual meeting of the Association for Re-search in Vision and Ophthalmology.

Pasadena, CA-A research and supply partnership will combine Carl Zeiss Meditec AG's digital light delivery system with Calhoun Vision Inc.'s light-adjustable lens (LAL).

Fort Lauderdale, FL-In a comparison of the comfort of two non-steroidal anti-inflammatory drug (NSAID) formulations, ketorolac tromethamine ophthalmic solution 0.4% with benzalkonium chloride (BAK) (Acular LS, Allergan) seemed to be as comfortable as preservative-free ketorolac tromethamine ophthalmic solution 0.5% (Acular PF, Allergan) based on ratings by 45 healthy volunteers who received two doses of the drops in a randomized, investigator-masked, single-center clinical trial

Fort Lauderdale, FL- In a preliminary mouse model study of corneal epithelial permeability and barrier function, several differences were found be- tween gatifloxacin ophthalmic solution 0.3% (Zymar, Allergan) and moxifloxacin ophthalmic solu- tion 0.5% (Vigamox, Alcon) but the significance of these findings is unclear, ac- cording to Stephen C. Pflugfelder, MD, who presented a poster on this study at the annual meeting of the Association for Research in Vision and Ophthalmology

By far, most patients surveyed considered efficacy of medication to be more important than possible side effects.

Fort Lauderdale, FL-The investigational drug tin ethyl etiopurpurin (SnET2) produced a visual acuity benefit and slowed the development of neovascular lesions in two phase III trials of SnET2 photodynamic therapy (PDT) (Miravant Medical Technologies) for the treatment of subfoveal choroidal neovascularization associated with wet age-related macular degeneration, said Edgar L. Thomas, MD, Retina-Vitreous Associates, Los Angeles.

Fort Lauderdale, FL-Prior pseudophakia appears to be a risk factor for trabeculectomy failure in eyes with uveitic glaucoma, said K. Sheng Lim, MD, at the annual meeting of the Association for Research in Vision and Ophthalmology.

Fort Lauderdale, FL-Experience with implantation of the Ex-PRESS miniature glaucoma device (Optonol Ltd.) under a scleral flap in high-risk eyes shows that it is a simple and effective technique for controlling IOP and reduces complications encountered with subconjunctival implantation, said Trevor R. Carmichael, MD, PhD, at the annual meeting of the Association for Research in Vision and Ophthalmology.

Fort Lauderdale, FL-Results of the OPTIME Study show that cardiovascular risk factors are significantly more prevalent among patients with primary open-angle glaucoma (POAG) compared with unaffected controls, reported Nicola Orzalesi, MD, PhD, at the annual meeting of the Association for Research in Vision and Ophthalmology.

New York-Results of an in vitro susceptibility study suggest a combination regimen consisting of clarithromycin and a fourth-generation fluoroquinolone may offer the best topical treatment for keratitis due to non-tuberculous Mycobacteria, said Mahendra K. Shah, MS.

A new artificial cornea may offer hope to patients who have a history of multiple human donor cornea rejections. AlphaCor, manufactured by Australian-based Argus Biomedical Pty Ltd. and marketed by CooperVision Surgical Inc., is a biocompatible, flexible, one-piece artificial cornea that has been designed to replace a scarred or diseased native cornea in patients for whom corneal graft using human donor tissue is unsuitable.

Rishon Le-Zion, Israel-LASEK performed by using hypertonic saline (5% NaCl) to lift the flap may be a better alternative to alcohol-assisted LASEK, according to a recent randomized prospective study. Israeli researchers presented clinical trial results of the new method.

New York-Research to Prevent Blindness (RPB), announced 44 new grants totaling $4.8 million for investigations into the causes, treatment, and prevention of all blinding diseases.

Fort Lauderdale, FL-In a comparison study that has implications for wound healing in surface ablation procedures, investigators found that four commonly used topical ophthalmic antibiotics-moxifloxacin (Vigamox, Alcon), levofloxacin (Quixin, Santen), gatifloxacin (Zymar, Allergan), and ofloxacin (Ocuflox, Allergan)-all showed evidence of toxicity on human corneal epithelial cells, with moxifloxacin causing the least amount of toxicity.

Salt Lake City-A $100,000 grant to the University of Utah's John A. Moran Eye Center will support continued research into retinal cell transplantation in the treatment of retinitis pigmentosa (RP).

New York-Columbia University Medical Center is hoping its new Louis V. Gerstner Jr. Clinical Research Center in Vision will help to develop solutions to the world's most pressing vision problems.

Fountain Hills, AZ-Coronado Industries Inc. has received 2A CE certification from the European Union for its proprietary pneumatic device for glaucoma treatment.

Fort Worth, TX-Alcon Inc. has filed the second of three parts of its "rolling" new drug application for anecortave acetate for depot suspension (Retaane) 15 mg, an investigational treatment for patients with wet age-related macular degeneration (AMD).

Tampa, FL-Ted Newill, the president of Talia Technology Inc., is stepping down after 3 years at the helm.

Irvine, CA-IntraLase Corp. sold 30 lasers during its second quarter ended June 30, bringing the total number of its lasers to 153 units globally.

Santa Ana, CA-Advanced Medical Optics Inc. (AMO) is offering an extended low-diopter and plano range of its Array silicone IOL.

San Diego-U.S. Naval aviators can benefit from PRK in terms of restoration of visual acuity to 20/20 and enhanced flight performance, said David J. Tanzer, MD, surgical director, refractive surgery center, department of ophthalmology, Naval Medical Center, San Diego.

Fort Lauderdale, FL-More aggressive glaucoma screening methods and a better understanding of disease progression as well as its incidence and prevalence among various population groups are essential to lessening the devastating impact of this disease worldwide, said Harry A. Quigley, MD, during the 2004 Friedenwald Award lecture at the Association for Research in Vision and Ophthalmology (ARVO) annual meeting.