Pharmacy

Tampa, FL-Sirion Therapeutics Inc. agreed to receive exclusive U.S. licensing rights to a topical ophthalmic emulsion containing difluprednate, a steroid compound that may treat inflammatory eye diseases.

Oakbrook Terrace, IL-The Joint Commission on Accreditation of Healthcare Organizations (JCAHO) issued 2007 National Patient Safety Goals for ambulatory care facilities and offices in which surgery is performed.

Irvine, CA-Senju Pharmaceuticals will transfer exclusive North American rights of two investigational drugs-iganidipine, a calcium-channel blocker, and a new formulation of latanoprost, a prostaglandin analogue-to ISTA Pharmaceuticals. Both investigational formulations may treat glaucoma or other ophthalmic applications.

Eli Lilly and Co. and Alcon Laboratories have reached an agreement to co-promote ruboxistaurin mesylate (proposed brand name, Arxxant) in the United States and Puerto Rico. The agreement is contingent upon FDA approval. The government agency is currently reviewing the oral drug as a treatment for moderate-to-severe nonproliferative diabetic retinopathy.

ISTA Pharmaceuticals filed a New Drug Application for its investigational tobramycin and prednisolone acetate in a fixed combination (T-Pred). The company hopes the drug receives approval as a treatment for inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial ocular infections or a risk of bacterial infections exists.

Philadelphia-Acuity Pharmaceuticals and ZaBeCor Pharmaceutical Co. entered into a license option agreement in which Acuity gains exclusive development and commercialization rights to ophthalmic applications of a small interfering RNA (siRNA).

Retinal specialists have a new therapy in their armamentarium for treating patients with neovascular age-related macular degeneration (AMD).

Identifying and prescribing the optimum non-steroidal anti-inflammatory drug (NSAID) to help patients get the best possible LASEK result is a crucial part of the surgical treatment plan. Likewise, postoperative non-compliance can weaken the outcome of an otherwise perfect procedure.

Fort Lauderdale, FL-An investigational longacting solution of 1.0% azithromycin (AzaSite, InSite Vision) is safe, well tolerated, and effective for the treatment of bacterial conjunctivitis in pediatric patients and adults, according to the results of pivotal phase III clinical trial involving placebo and active controls.

ISTA Pharmaceuticals gained exclusive North American rights to Senju Pharmaceuticals' iganidipine, a calcium-channel blocker, and a new formulation of latanoprost, a prostaglandin analogue.

ISTA Pharmaceuticals gained exclusive North American rights to Senju Pharmaceuticals' iganidipine, a calcium-channel blocker, and a new formulation of latanoprost, a prostaglandin analogue.

Compared with placebo, ruboxistaurin mesylate ( proposed brand name , Arxxant, Eli Lilly and Co.) reduces the risk of sustained moderate vision loss by 41% in patients with moderate-to-severe nonproliferative diabetic retinopathy, according to pooled data from two 3-year phase III trials. Eli Lilly and Co. presented the findings at the American Diabetes Association's annual scientific sessions recently.

(OSI) Eyetech Pharmaceuticals Inc. and Pfizer Inc. have initiated a phase IV trial that will study whether use of pegaptanib sodium injection (Macugen) following neovascular age-related macular degeneration (AMD) therapy provides a balance in long-term safety and efficacy. Called LEVEL (EvaLuation of Efficacy and safety in maintaining Visual acuity with sEquential treatment of neovascuLar AMD), the 54-week trial will comprise up to 1,000 patients at 100 sites across the country.

The femtosecond pulses offer real, precise subsurface effects, with the least amount of energy required.

The femtosecond pulses offer real, precise subsurface effects, with the least amount of energy required.

The use of hormonal therapies may represent the next generation of medication for the tear film deficiencies of dry eye.

South San Francisco, CA - Genentech Inc. announced on Friday, June 30, 2006 that the FDA has approved its ranibizumab 0.5 mg injection (Lucentis, Genentech Inc.) for the treatment of neovascular (wet) age-related macular degeneration (AMD). The FDA approved Lucentis after a 6-month priority review, the company said. Genentech will begin shipping product immediately. Ninety-five percent of patients treated with Lucentis maintained their vision in phase III clinical trials, according to the company. Vision improved by at least three lines (or 15 letters) on the study eye chart in up to 40% of these patients at 1 year. Lucentis was developed for intraocular use to treat the underlying cause of wet AMD by targeting the molecular pathway that controls angiogenesis. Lucentis is designed to bind and inhibit VEGF-A, a protein that is believed to play a critical role in angiogenesis.

South San Francisco, CA - Genentech Inc. announced on Friday, June 30, 2006 that the FDA has approved its ranibizumab 0.5 mg injection (Lucentis, Genentech Inc.) for the treatment of neovascular (wet) age-related macular degeneration (AMD). The FDA approved Lucentis after a 6-month priority review, the company said. Genentech will begin shipping product immediately. Ninety-five percent of patients treated with Lucentis maintained their vision in phase III clinical trials, according to the company. Vision improved by at least three lines (or 15 letters) on the study eye chart in up to 40% of these patients at 1 year. Lucentis was developed for intraocular use to treat the underlying cause of wet AMD by targeting the molecular pathway that controls angiogenesis. Lucentis is designed to bind and inhibit VEGF-A, a protein that is believed to play a critical role in angiogenesis.

San Francisco-Studies with the accommodating IOL (crystalens, eyeonics) are providing new insights regarding its mechanism of action that help to explain why some patients have achieved near vision that is much better than expected.

The FDA approved WaveLight Inc.'s wavefront-optimized Allegretto Wave excimer laser system for the treatment of mixed astigmatism. The indication is to reduce or eliminate naturally occurring mixed astigmatism of up to 6 D at the spectacle plane.

Overall, acute endothelial cell loss rates were about 6% for boththe central and peripheral cornea.

Farmers Branch, TX-Corporate, state, and local officialsjoined together recently to break ground on Essilor of America'snew U.S. corporate campus. Development of the campus is planned asa 5-year process. Phase one will redevelop existing structures andconstruct new buildings to create 270,000 square feet of space.

Baltimore-Intravitreal injection of a small interfering RNAmolecule (Sirna-027, Sirna Therapeutics Inc.) appears to be safeand well tolerated by patients for treatment of choroidalneovascularization (CNV) secondary to age-related maculardegeneration (AMD), according to Edward J. Quinlan, MD, whoreported the preliminary data from the phase I clinical trial.

New York-Pfizer Inc. is looking to boost shareholder earningsby studying options-including a sale or spin-off-forits over-the-counter (OTC) drug unit, which includes the Visineline of eye drops.

Exton, PA-Othera Pharmaceuticals Inc. has announced theinitiation of a phase II clinical trial by the National EyeInstitute (NEI) of Othera's topical eye drop OT-551 in patientswith geographic atrophy (GA). The NEI will investigate OT-551'spotential to slow enlargement of the atrophic area in the maculaand prevent progression to the vision-threatening advanced stagesof age-related macular degeneration (AMD).

Irvine, CA-The Committee for Medicinal Products for Human Use(CHMP) has recommended that the European Commission approveGanfort, Allergan's bimatoprost (Lumigan)/timolol ophthalmicsolution combination product for glaucoma. The CHMP opinion servesas the basis for a European Commission approval, which is expectedto be finalized in the second quarter of 2006.

Atlanta-Alimera Sciences Inc. and pSivida Limited haveannounced that following a planned interim review, an independentData Safety Monitoring Board (DSMB) has recommended thecontinuation of their phase III clinical trial of Medidur.

The study of proteomics could identify candidate proteins thatmight be targets for pharmaceutical therapies for age-relatedmacular degeneration (AMD), said Deborah A. Ferrington, PhD,assistant professor in the departments of ophthalmology andbiochemistry, molecular biology and biophysics at the University ofMinnesota, Minneapolis.

Native Americans used their experience and were able to care for themselves very well.

New York?The Scleral Spacing Procedure (SSP) for Presbyopia with PresVIEW Scleral Implants (PSI) (Refocus Group Inc., formerly PresbyCorp) provides significant improvement in near visual acuity (VA) and no change in the uncorrected distance VA, according to Barrie D. Soloway, MD, FACS.