A novel topical high-concentrated, crosslinked hyaluronic acid eye drop could expand the options that surgeons have available for improving wound care, healing, and regenerative medicine for a variety of corneal injuries.
NOVEL HA EYE DROP
A novel and proprietary high-concentration, crosslinked HA eye drop was developed that withstands the forces of blinking and tear turnover on the ocular surface.3 Because of its remarkable physical properties as a highly concentrated crosslinked eye drop, this HA drop becomes a transparent and non-blurring fluid that shear thins under the force of the blinking eyelids. By providing a thin coating on the surface of the eye, it serves as a hydrating protectant and lubricant that facilitates acceleration of corneal re-epithelialization.1,4
This high-concentration (0.75%), crosslinked HA has demonstrated to provide a mechanical barrier that aids in the management of corneal epitheliopathies and accelerates re-epithelialization in animals with traumatic corneal injuries and non-healing persistent corneal defects. This has been demonstrated in preclinical studies,2 as well as in "real-world" clinical ophthalmic veterinary use in dogs and cats.3-6
Given the tremendous unmet need in humans for a well-tolerated and easy-to-apply HA agent that can hydrate, lubricate, and accelerate corneal wound repair, EyeGate Pharmaceuticals (Waltham, MA) conducted the first in-human study to evaluate the efficacy of this formulation of HA in subjects with large corneal defects.
"HA is a well-known and trusted substance, but based on the early work in photorefractive keratectomy (PRK) patients, this formulation appears to be very unique," said Dan Durrie, MD, Durrie Vision, Overland Park, KS. "Clinical trials in PRK patients don't necessarily represent the greatest need, but (they) are a very good model to demonstrate wound-healing capabilities, which should have broader applications for our patients.
"I'm excited to see the results of the upcoming trials and where this will lead in treating a variety of epitheliopathies, including dry eye," Dr. Durrie added
BARBARA WIROSTKO, MD
E: [email protected]
Dr. Wirostko is chief medical officer for EyeGate Pharmaceuticals; co-founder of Jade Therapeutics; and adjunct professor of ophthalmology, Moran Eye Center, University of Utah, Salt Lake City. She is also a stockholder in EyeGate.
1. Wirostko B, Mann BK, Williams DL, Prestwich GD. Ophthalmic uses of a thiol-modified hyaluronan-based hydrogel. Adv Wound Care (New Rochelle) 2014; 3:708-716.
2. Yang G, Prestwich GD, Mann BK. Thiolated carboxymethyl-hyaluronic-Acid-based biomaterials enhance wound healing in rats, dogs, and horses. ISRN Vet Sci 2011; Article ID 851593. doi: 10.5402/2011/851593. Accessed July 7, 2017 at http://dx.doi.org/10.5402/2011/851593
3. Williams DL, Mann BK. A crosslinked HA-based hydrogel ameliorates dry eye symptoms in dogs. Int J Biomater 2013, Article ID 460437. Accessed July 7, 2017 at http://dx.doi.org/10.1155/2013/460437
4. Yang G, Espandar L, Mamalis N, Prestwich GD. A crosslinked hyaluronan gel accelerates healing of corneal epithelial abrasion and alkali burn injuries in rabbits. Vet Ophthalmol 2010; 13:144-150.
5. Williams DL, Wirostko BM, Gum G, Mann B. Topical crosslinked HA-based hydrogel accelerates closure of corneal epithelial defects and repair of stromal ulceration in companion animals. Invest Ophthalmol Vis Sci. 2017;58:4616-4622. doi: 10.1167/iovs.16-20848.
6. Williams DL, Mann BK. Efficacy of a crosslinked hyaluronic acid-based hydrogel as a tear film supplement: a masked controlled study. PLoS ONE 2014; 9: e99766. doi:10.1371/journal.pone.0099766. Accessed July 7, 2017 at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099766
7. Daniel S. Durrie MD, Darcy Wolsey, MD, MPH, Vance Thompson, MD, Carol Assang, Brenda Mann, PhD, Barbara Wirostko, MD. Accelerating re-epithelialization after photorefractive keratectomy with an ocular bandage gel. Journal of Cataract and Refractive Surgery. Accepted and in press Nov 2017.